Efficacy of MgSO4 as an adjunct to Ropivacaine and Fentanyl for labour analgesia
Authors: Sadia Ali Wani, Basharat Hussain Pandit, Ubaid Ullah Gul Salmani, Sadaf Ali Wani
Abstract:Background and Objective: Epidural analgesia provides effective pain relief, less maternal stress response, better patient satisfaction. The main aim of this study was to evaluate the efficacy of Magnesium Sulphate as an adjunct to ropivacaine and fentanyl for labor analgesia. Materials and Methods: This randomized prospective study recruited 60 primi parturients, aged > 18 years, ASA class II, in active labor, requesting labor analgesia. Patients were divided into 2 groups: Group F and Group FM. Group F received 7.5 ml 0.2% Ropivacaine + 50 mcg Fentanyl + Normal Saline to make a total volume of 10 ml and in Group FM patients received 7.5 ml 0.2% ropivacaine + 50 mcg fentanyl + 50 mg Magnesium Sulphate + Normal Saline to make a total volume of 10 ml. Pain was assessed using Visual Analogue Scale (VAS). Time of onset, quality of analgesia and duration of analgesia of bolus doses were noted. Results: Single Epidural dose of Magnesium Sulphate added to ropivacaine and fentanyl resulted in significantly early onset (2.9 ± 0.7 minutes v/s 5.2 ± 1.1 minutes, P < 0.001) and longer duration (107.2 ± 20.1 minutes v/s 89.9 ± 21.3 minutes, P = 0.002) as compared to patients who received ropivacaine and fentanyl only. There was no significant effect on neonatal outcome (assessed by APGAR Score) and no maternal side effects were recorded. Conclusion: Magnesium sulphate added to ropivacaine and fentanyl for labor analgesia resulted in early onset of analgesia and longer duration of action without any significant side effects.
Published on: 31-07-2020