Markers of Inflammation in Rheumatoid Arthritis and Osteoarthritis
Authors: Nutan Y. Chaudhari , A.N.Sontakke
Abstract:Introduction: Rheumatoid arthritis is characterized by local and systemic effects of inflammation while osteoarthritis is an inflammatory degenerative disorder of joints. A wide range of inflammatory markers are implicated in pathogenesis of rheumatoid arthritis and osteoarthritis as a consequence of persistent imbalance between pro- and anti-inflammatory immune mechanisms, leading to chronic inflammation. Hence the present study is an attempt to estimate the levels of serum ceruloplasmin , C-reactive protein (CRP) and rheumatoid factor (RF) factor as inflammatory markers in serum of rheumatoid arthritis and osteoarthritis patients and compare them with normal healthy controls. Materials and Methods: Serum ceruloplasmin was estimated by spectrophotometric method while serum C-reactive protein and RA factor were detected using agglutination test in thirty patients of rheumatoid arthritis ,osteoarthritis and age and sex matched healthy controls each were included in the study. Results: Significant increase in ceruloplasmin was observed (p<0.0001) in rheumatoid arthritis and osteoarthritis as compared to healthy controls and in that especially ceruloplasmin was more elevated in rheumatoid arthritis than osteoarthritis. C-reactive protein was found to be positive in rheumatoid arthritis and osteoarthritis and none of the controls. RF factor was found positive in rheumatoid arthritis and none of the osteoarthritis and controls. Conclusion: There was increased level of serum ceruloplasmin in the patients with rheumatoid arthritis and osteoarthritis. C-reactive protein and RF factor was found to be positive in rheumatoid arthritis while C-reactive protein was found to be positive in rheumatoid arthritis and osteoarthritis. These findings suggest a possible role of these inflammatory markers in the pathogenesis of rheumatoid arthritis.
Published on: 30-05-2020