Response rate to vaccination against Hepatitis B virus among health care workers at St. Dominic Hospital, Akwatia, Ghana
Authors: AmoakoDuah, AdwoaAgyei Nkansah, Evelyn Amoako, Maite Alfonso Romero, Rafiq Okine, Francisca Duah
Abstract:Background: Hepatitis B is a major contributor to the burden of infectious diseases worldwide. Many preventive measures have been employed, however, active immunization with hepatitis B vaccine remains the single most important hepatitis B prevention measure. WHO recommends that all health care workers (HCWs) should be vaccinated against HBV. However, proportions of individuals do not respond to the recommended standard three dose of HBV vaccination and remain susceptible to the infection.Objectives: This study was to assess the response rate to vaccination against HBV among health care workers and to determine predictors of non-response to HBV vaccine in HCWs. Methods and Materials: A prospective study carried out at the Saint Dominic Hospital, Akwatia, involving 100 HCWs from 29th August, 2018 to 4th June, 2019. All the participants received the standard protocol of 3 intramuscular injections of HBV vaccine (Engerix B) at 0, 1, and 6 months. Qualitative and quantitative serum anti-HBs was determined 1-2 months after the last injection in order to detect the responders and non-responders.Results: Majority (54.0%) of the participants were males. The Median age of the study participants was 35 (29, 47) with age range of 20-65 years. Out of the 100 HCWs 90 (90%) were responders and 10 (10%) were non-responders to hepatitis B vaccine. Non-responders had increased odds of being female, though this was not statistically significant (COR=1.47 (0.42 - 5.17).Conclusion: All HCWs should undergo confirmatory testing of immune response after completion of scheduled standard HBV immunization. This will ensure safety of all HCWs against HBV infection.
Published on: 24-10-2019