Changes in Platelet Indices in Obese and Non-Obese Individuals in a Tertiary Healthcare Facility in Uyo, Nigeria
Authors: Timothy Amos Ekwere, OlugbemiOluseyiMotilewa
Abstract:Background: Obesity is associated with significant cardiovascular and thromboembolic risk largely due to increased platelet reactivity. Objectives: To determine the changes in platelet counts and platelet activation using platelet indices (MPV & PDW) in obese and non-obese patients in a tertiary hospital in Uyo, Nigeria.Methodology: This was a cross-sectional descriptive study comprising of 191 participants recruited consecutively from the out-patients Departments of University of Uyo Teaching Hospital over a six months period (March-August 2018). Patients were categorised into obese, overweight and normal weight based on their Body Mass Index (BMI). Also, 2.5mls of blood was collected from each patient and same was used to determine full blood count from where the platelet count and platelet indices (MPV & PDW) were obtained. Results: There was progressive increase in the mean platelet count of the patients (210.59 ± 51.6, 194.26 ± 49.8, 184.95 ± 51.7 for obese, overweight and normal weight respectively) and this increase was statistically significant (P=0.0208). However, the mean platelet indices (MPV & PDW) was not statistically significant (P=0.351 and 0.933 for MPV and PDW respectively). Conclusion: Platelet counts was significantly elevated in obese patients compared with the overweight and normal weight however, the MPV and PDW was not significantly different in the three groups.
Published on: 24-10-2019