Non Invasive Evaluation of Residual Disease in Women of Locally Advanced Breast Cancer after Neoadjuvant Chemotherapy
Authors: Maj (Dr)Vasu Nikunj
Abstract:Background: The aim of this study was to evaluate the role of Neoadjuvant Chemotherapy (NACT) in Locally Advanced Breast Cancers (LABC) by correlating the clinical and radiological findings before and after NACT. Methods: A prospective study conducted over a 2yr period, enrolled patients with LABC. All patients were evaluated clinically and radiologically before and after completion of NACT. Breast lump size, axillary nodal metastasis and features of locoregional involvement were recorded. The incidence of complications and locoregional recurrence were also noted. Results: Out of total 100 patients, maximum(n= 72) showed partial response ( PR) and 02 showed no response. There was a decrease in mean tumor size (4.91cm vs 2.74 cm, p=<0.001) on clinical examination and (4.14cm vs 2.24cm, p= <0.001) on radiological evaluation. Mean lymph node size decreased to (1.34cm vs 0.04 cm, p= <0.001) on clinical examination and (9.95mm vs 0.52m, p=<0.001) on radiological evaluation. There was no case of locoregional recurrence on follow up. Conclusions: The implication of this study is that NACT helps in down staging of the tumors and for better clinical evaluation, both physical examination and radiological evaluation should be routinely used in the patients of LABC undergoing NACT.
Published on: 03-05-2019