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Efficacy of Oxytocin and Misoprostol versus Oxytocin infusion in the prevention of postpartum hemorrhage after caesarean section

Authors: UshaBrindhini Mathialagan, Vanaja Kandluri, Varsha Suma, Sanakula Jahnavi, Tapala Pallavi, Thunga Veronica
Abstract:Background: Postpartum hemorrhage (PPH) is the most common cause for maternal death. Nowadays incidence of PPH has reduced because of uterotonic drugs. In our study, we have compared the efficacy of intravenous oxytocin and rectal misoprostol versus oxytocin infusion in preventing PPH after caesarean section.Material and Methods: It is a prospective cross-sectional study.A total of 50 pregnant women were enrolled in the study who were divided into two groups. Group ‘A’ included 25 primigravida / multigravida with singleton pregnancy who underwent caesarean section. They all received 10 IU intravenous oxytocin after the delivery of baby. Group ‘B’ included equal number of primigravidas/multigravida with singleton pregnancy, who underwent caesarean section and received 600μg of misoprostol per rectally and 10 IU oxytocin intravenouslyafter delivery of the baby.Results:In both the groups, most of the study subjects were in the age group of 20-25 years (44% versus 48%). The mean blood loss in Group A was found to be 750 ±185.40ml whereas in Group B it was 772±311.06ml. The mean Pre operativeHb in Group A was found to be 11.48±1.49gm/dl and in Group B, it was 11.57±1.60gm/dl. We observed the mean post operative blood loss for a period of 24 hrs after Cesarean section is not statistically significant in the two groups studied (p = 0.76). The difference between pre operative and post operative Hb values is not statistically significant.Conclusion: Simultaneous administration of oxytocin and misoprostol has no advantage over oxytocin alone.
Year: 2018
Month: July
Volume: 7
Issue: 3
Published on: 18-07-2018