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Effect of Coronary Reperfusion Therapy on Inflammatory Markers, Adiponectin and Insulin Resistance in Ischemic Patients

Category ORIGINAL_ARTICLE
Authors Hamed Mohamed Osman, Khaled Ahmad El Kashab, Amani M. El Amin Ali, Ahmed MagdyElebiary, Ahmed Desoky Badawy
Abstract Background: Patients who underwent percutaneous coronary interventions (PCI) and surgical coronary artery bypass grafting (CABG) for coronary artery disease may have inflammatory response. Insulin resistance-associated dysfunction of lipid metabolism can promote both systemic and local inflammatory responses that participate in the development of coronary artery disease. Objective: The aim of our work is to determine the changes in serum adiponectin level, high sensitive C-reactive protein in patients who underwent PCI and surgical CABG for coronary artery disease and compare the effect of both revascularization procedures on these parameters in non-diabetic ischemic patients after one month. Also we investigated whether or not there was a relation between their levels and insulin resistance. Materials and Methods: 40 patients with ischemic heart disease who underwent the procedure of reperfusion therapy are reevaluated one month after intervention by either PCI or CABG. Serum adiponectin, insulin & high sensitive C-reactive protein were measured and insulin resistance was assessed using HOMA-IR index. Results: High sensitive C reactive protein, Insulin and adiponectin levels decreased significantly in patients after PCI with p-value <0.05.One month after revascularization, high sensitive C reactive protein and adiponectin levels were significantly higher in patients exposed to CABG in comparison to patients exposed to PCI. Insulin resistance as indicated by HOMA-IR was elevated in patients one month after CABG with p-value <0.05. Conclusion: PCI causes less reperfusion injury compared to CABG procedure depending on high sensitive C-reactive protein as predictor of reperfusion injury after revascularization by PCI in ischemic patients. KEYWORDS:Adiponectin, Coronary artery revascularization, High sensitive C-reactive protein, Insulin resistance.
Year 2018
Month April
Volume 7
Issue 2
Published On 19 Apr 2018
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