| Category | ORIGINAL_ARTICLE |
|---|---|
| Authors | Anitha Chauhan Palthiya, Nazneen Zara, Sana Bushra, Manchala Raghunath |
| Abstract | Background: Fenugreek is known for its anti-diabetic properties. Although different compounds in it have been proposed to be active, the actual active component(s) is(are) still to be established. Objective: To find out the antidiabetic effect of fenu fibre in freshly diagnosed type2 diabetic subjects. Materials and Methods: Anti-diabetic properties of fenugreek fibre, the outer coat of the fenugreek seeds, were assessed by supplementing it to freshly diagnosed (3-6month duration) type 2 Diabetes Mellitus (T2DM) patients for a duration of 45 days. Results: Chronic supplementation of fenu - fibre @ 15g/day, significantly reduced the fasting plasma glucose and insulin resistance as assessed by HOMA–IR, whereas beta cell function (HOMA β%) was significantly increased. It decreased the area under curve (AUC) of glucose during the oral glucose tolerance test (OGTT) but not plasma insulin: fasting or post glucose load, suggesting improved insulin sensitivity. Plasma HDL cholesterol was increased whereas plasma total cholesterol and triglycerides were unaffected, indicating a marginal effect on lipid profile. Conclusion: Supplementation of fenu-fibre to freshly diagnosed T2DM patients improved their glycaemic status and increased insulin sensitivity / beta cell function may underlie this effect. KEYWORDS: Fenu-fibre, type2 Diabetes |
| Year | 2018 |
| Month | January |
| Volume | 7 |
| Issue | 1 |
| Published On | 22 Jan 2018 |
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