| Authors |
Allan Hilario*, Maria Joanne Dente, Kristine Daryll Fabellon, Rozelle Garcia, Faizal Guiamano, Frederick Allen Herrera, Marvin Gil Hitosis, Maikka Ilagan, Sean Russell Layton, Phylis Rio, Geraldine Susan Tengco, Danilo Menorca |
| Abstract |
Introduction: Several herbal medicines have hypouricemic effect due to their antioxidant property and inhibition of xanthine oxidase. Curcuma longa, known as turmeric, has several medicinal properties. Studies on its hypouricemic property are limited. This study aimed to determine the hypouricemic property of crude ethanolic extract of C. longa rhizome on potassium oxonate-induced hyperuricemic mice. Materials and Methods: Twenty male BALB/c mice were randomly assigned into four groups (n=5). At hour 0, the Vehicle Group (VG) received 0.5 ml of phosphate buffered solution (PBS) intraperitoneally (ip); Negative Group (NG) received 0.25 ml of PBS and 0.25 ml of potassium oxonate (200 mg/ml) ip; Treatment Group (TG) received similar dose of potassium oxonate and 0.25 ml of the crude ethanolic extract of C. longa rhizome (300 mg/ml) ip; and the Positive Group (PG) received similar dose of potassium oxonate and 0.25 ml of allopurinol (300 mg/ml) ip. Four hours later, blood collection was done and uric acid levels were determined. Statistical analysis done with P-value set at <0.05. Results: Major findings showed that the mean uric acid level of TG group was significantly lower than the NG group (477.6 ± 80.2 vs. 1,875.5 ± 429.5 μmol/l; P<0.05). The mean uric acid level of TG group was not significantly different when compared with VG (390.5 ± 22.7 μmol/l) and PG (325.6 ± 44.0 μmol/l; P>0.05). Conclusion: These findings showed that the crude ethanolic extract of C. longa rhizome has hypouricemic potential for pharmacologic application.
KEYWORDS: Curcuma longa, hyperuricemia, hypouricemic property, mice model |
